Journal article

FEF25–75% trajectories from age 7 to 53 years, associations with childhood and parental preconception factors, and midlife COPD risk: a prospective cohort study

J Liu, CJ Lodge, JL Perret, D Vicendese, NS Idrose, DJ Tan, AJ Lowe, G Bowatte, GS Hamilton, B Erbas, RJ Adams, I Feather, CR Jenkins, D Martino, GD Mishra, SO Shaheen, GR Washko, JW Holloway, C Svanes, RR Wood-Baker Show all

Lancet Respiratory Medicine | Elsevier BV | Published : 2026

DOI: 10.1016/S2213-2600(26)00163-3

Open access

Abstract

Background: Existing trajectory studies have emphasised large-airway indices, but chronic obstructive pulmonary disease (COPD) might originate in smaller airways. This study aimed to investigate mid-to-small-airway function trajectories, their associated factors, and COPD risk. Methods: In this prospective cohort study, probands (referred to throughout as offspring) were recruited to the Tasmanian Longitudinal Health Study from local schools across Tasmania, Australia at age 7 years. Pre-bronchodilator mean forced expiratory flow between 25% and 75% of the forced vital capacity (FEF25–75%) of offspring was measured at age 7 years as a proxy measure of mid-to-small-airway function. Parents co..

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Keywords

Prevention
2.3 Psychological, Social and Economic Factors
3201 Cardiovascular Medicine and Haematology
Chronic Obstructive Pulmonary Disease
3202 Clinical Sciences
Clinical Research
Asthma
Lung
2.1 Biological and Endogenous Factors
32 Biomedical and Clinical Sciences
Pediatric Research Initiative
Respiratory